What Are GLP-1 Agonists?
GLP-1 agonists are peptides that work by mimicking the actions of the glucagon-like peptide-1 hormone, aiding in blood sugar regulation and promoting a feeling of fullness. Common examples of GLP-1 agonist medications include:
Dulaglutide (Trulicity)
Exenatide extended-release (Bydureon BCise)
Exenatide (Byetta)
Semaglutide (Ozempic)
Liraglutide (Victoza, Saxenda)
Lixisenatide (Adlyxin)
Semaglutide (Rybelsus)
Tirzepatide (Mounjaro)
How Do GLP-1 Agonists Help You Lose Weight?
GLP-1 agonists assist in weight loss by helping control overall calorie consumption. This is achieved in two key ways. Firstly, they slow gastric emptying, keeping food in the stomach longer and extending post-meal fullness. This reduces the urge to eat frequently or avoid excessive overeating.
Secondly, these medications positively impact the brain’s satiety centers, responsible for signaling when we are full. By stimulating these centers, GLP-1 agonists promote satisfaction with smaller food portions, further supporting reduced total calorie intake. Together, these enable GLP-1 agonists to be effective in weight loss strategies.
Understand the Clinical Evidence Supporting GLP-1 Agonists for Obesity
A 2011 study published in the British Medical Journal revealed that GLP-1 receptor agonists led to an average weight loss of 2.9 kg (approximately 6.4 lbs) in obese diabetic and non-diabetic individuals. Similarly, a 2021 review published in Advances in Therapy affirmed the weight reduction benefits of GLP-1 agonists like liraglutide and semaglutide.
A 2023 review of research published in the International Journal of Obesity showed significant reductions in body weight, BMI, and waist circumference, particularly highlighting semaglutide’s effectiveness. Complementing this, a review published in The American Journal of Clinical Nutrition shed light on the cardiovascular advantages of GLP-1 agonists, suggesting their role goes beyond weight management to reduce heart-related risks in obese patients.
These studies collectively demonstrate the potential of GLP-1 agonists as an effective tool in combating obesity, offering hope to those who struggle with weight management and associated health risks.
Are You a Good Candidate for GLP-1 Agonists for Weight Loss?
While GLP-1 agonists work well for controlling blood sugar and helping with weight loss, it’s important to remember that they aren’t suitable for everyone, including pregnant individuals or those with certain pre-existing health conditions, like a history of pancreatitis, or thyroid cancer.
It is critical to consult a healthcare professional to understand the benefits and risks of starting a GLP-1 agonist and determine if it fits you.
What side effects are associated with GLP-1 agonists?
Common side effects include nausea, vomiting, diarrhea, constipation and decreased appetite, with possible injection site reactions. Serious side effects like pancreatitis or kidney issues are less common.
Can GLP-1 agonists be combined with other weight-loss medications?
Yes, but only under medical supervision. The safety and effectiveness of combining medications will depend on a patient’s individual health conditions and the specific medications involved.